Women reach fertility tipping point at age 49 even with donor eggs

Researchers have identified age‑related alterations in the uterine lining, or endometrium, as a potential factor behind declining fertility in older women. The findings, published in a peer‑reviewed gynecology journal, stem from a multi‑center study that examined endometrial tissue samples from more than 300 participants ranging from their twenties to late forties. Microscopic analysis revealed a progressive thinning of the lining, reduced vascular density, and changes in cellular composition that correlated with decreased implantation rates observed in assisted‑reproductive‑technology cycles.

Experts say the discovery opens a pathway for therapeutic interventions aimed at restoring endometrial health. Ongoing trials are evaluating hormonal modulators and regenerative‑medicine approaches, such as stem‑cell therapy, to reverse or mitigate the identified changes. If successful, these treatments could extend reproductive potential and reduce age‑related infertility, though further clinical validation is required before they become widely available.