Estimated glucose disposal rate inversely linked to benign prostatic hyperplasia

A recent study published online on August 25 in *The Aging Male* reports a negative association between estimated glucose disposal rate (eGDR) and benign prostatic hyperplasia (BPH) in men. eGDR, a surrogate marker of insulin sensitivity, was calculated for a cohort of adult males and compared with clinical assessments of prostate enlargement. The researchers found that lower eGDR values, indicating poorer insulin sensitivity, correlated with higher prevalence and severity of BPH symptoms.

The investigators analyzed data from a cross‑sectional sample of men aged 50 to 75, controlling for age, body mass index, and comorbidities such as hypertension and dyslipidemia. After adjusting for these factors, each unit decrease in eGDR was associated with a statistically significant increase in the likelihood of clinically diagnosed BPH. The authors suggest that insulin resistance may contribute to prostatic growth through metabolic and inflammatory pathways, although causality cannot be established from this observational design.

These findings highlight a potential link between metabolic health and prostate disease, underscoring the importance of managing insulin sensitivity as part of comprehensive care for aging men. Further longitudinal studies are needed to determine whether improving eGDR can reduce BPH incidence or progression.