13-Lab Indicator Model Detects Heart Failure with Reduced Ejection Fraction

A new laboratory‑based scoring system that incorporates 13 routinely measured blood indicators has demonstrated moderate ability to differentiate patients with heart failure with reduced ejection fraction (HFrEF) from other cardiac conditions, according to research published online on August 9 in *Frontiers in Cardiovascular Medicine*. The investigators developed the model using data from standard clinical chemistry panels and evaluated its performance against established diagnostic criteria for HFrEF.

The analysis showed that the 13‑indicator model achieved moderate discrimination, suggesting it can serve as an adjunct tool in the initial assessment of suspected HFrEF, particularly in settings where advanced imaging may be limited. By relying on commonly available laboratory tests, the approach offers a potentially cost‑effective means to flag patients who warrant further cardiac evaluation.

The authors conclude that while the model’s discriminative power is not sufficient to replace echocardiography, it may help streamline the diagnostic pathway for heart failure by identifying high‑risk individuals earlier. Further validation in larger, diverse cohorts is recommended before routine clinical implementation.